When Mark J. Plotkin, Ph.D. first stepped into a night class with Harvard ethnobotanist Richard Evans Schultes, the path of his life was instantly set. Almost 40 years later, Mark has participated in close to 100 ayahuasca ceremonies with Amazonian shamans, sampled numerous psychedelic plants from the rainforest, and partnered with multiple indigenous tribes to protect their lands and ecosystem. In this episode of the Third Wave podcast, Mark and Paul discuss Mark’s storied career, the importance of indigenous reciprocity and conservation, current and potential surprising uses for psilocybin, the crucial element of context when working with psychedelics, and more.